Product Description
4-Chloro-1-butanol (CAS No. 928-51-8) is an organic compound with the following characteristics:
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Chemical Properties:
- It is a clear, colorless liquid.
- It is soluble in methanol, chloroform, and dimethyl sulfoxide.
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Uses:
- 4-Chloro-1-butanol is used as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
- It is also employed in organic synthesis.
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Safety Information:
- It is considered a moderately toxic compound by ingestion and is suspected to be a carcinogen with experimental neoplastigenic data.
- The acute oral toxicity category is 4, and it is classified as a Category 1B skin corrosor/irritant and a Category 1 serious eye damage/eye irritant.
- It is also classified as a Category 3 specific target organ toxicity (single exposure) and is corrosive to metals.
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Physical Properties:
- The density is approximately 1.0892 g/cm³.
- The boiling point is 84-85°C at 16 mmHg.
- The flash point is 36°C.
- The vapor pressure is 0.3±0.7 mmHg at 25°C.
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Storage and Handling:
- It should be stored in a cool place, and the container should be kept tightly closed in a dry and well-ventilated area.
- It is advised to avoid contact with skin and eyes, and to avoid the formation of dust and aerosols.
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Fire-Fighting Measures:
- Suitable extinguishing media include water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
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Disposal:
- Tetramethylenchlorohydrin, a related compound, is burned in a chemical incinerator equipped with an afterburner and scrubber.
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Manufacturing:
- It is produced by the reaction of tetrahydrofuran with hydrogen chloride.
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