| Customization: | Available |
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| CAS No.: | 25333-42-0 |
| Formula: | N/a |
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(R)-3-Quinuclidinol is an important chiral building block used in the synthesis of various pharmaceuticals. It serves as a crucial intermediate for multiple medications with different therapeutic applications. Here are some of its primary uses:
Synthesis of Medications for Treating Obstructive Pulmonary Disease: (R)-3-Quinuclidinol is used in the production of drugs such as aclidinium bromide and revatropate, which are designed to treat obstructive pulmonary disease .
Treatment of Urinary Incontinence: It is a key intermediate in the synthesis of solifenacin, a drug used to treat urinary incontinence .
Parkinson's Disease Treatment: (R)-3-Quinuclidinol is also used in the synthesis of talsaclidine, a medication for treating Parkinson's disease .
Enzymatic Reactions: It is produced through the enzymatic reduction of 3-quinuclidinone using 3-quinuclidinone reductase, an enzyme that has been identified for its industrial potential in biocatalytic processes .
Stereospecific Reduction: (R)-3-Quinuclidinol can be obtained through the stereospecific reduction of 3-quinuclidinone by certain bacterial strains, such as those from the Nocardia and Rhodococcus genera, offering a new approach to the synthesis of this compound with high enantiomeric purity .
Catalyst in Organic Synthesis: It is used as a catalyst in the synthesis of various organic compounds, including the synthesis of aldols with methyl vinyl ketone .
Preparation of Cholinergic Agents: (R)-3-Quinuclidinol is used in the preparation of cholinergic agents and anesthetics .
Due to its significance in pharmaceutical synthesis, (R)-3-quinuclidinol is a compound of interest in both chemical and biological research, leading to the development of efficient and environmentally friendly methods for its production .
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