| Customization: | Available |
|---|---|
| CAS No.: | 9004-65-3 |
| Formula: | C3h7o* |
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Product name: Hypromellose E6
CAS No: 879-37-8
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
The full form of HPMC is Hydroxypropyl Methyl Cellulose. It features a cellulose backbone with substituents that enhance its water solubility and stability, making it suitable for various applications.
As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.[4] Its Codex Alimentarius code (E number) is E464.
Application and Effect
Hypromellose E6, also known as hydroxypropyl methylcellulose with a specific viscosity grade (E6 indicates a certain viscosity range), has the following common applications:
1. Pharmaceutical industry
Tablet coating:
Function: It is used to form a protective film on the surface of tablets. This coating can improve the appearance of tablets, making them more aesthetically pleasing. For example, it can give tablets a smooth and shiny finish. It also acts as a barrier, protecting the active pharmaceutical ingredients (APIs) from environmental factors such as moisture, oxygen, and light, which can otherwise cause degradation of the drugs.
Release control: Hypromellose E6 can be formulated to achieve different drug - release profiles. In immediate - release tablets, it helps in the quick disintegration of the coating and release of the drug. In modified - release tablets, it can be used to control the rate of drug release, either by forming a slowly eroding matrix or by acting as a semi - permeable membrane in osmotic - release systems.
Capsule production:
Function: Hypromellose E6 is used as a substitute for gelatin in vegetarian or hypoallergenic capsules. It has good film - forming properties, allowing for the production of strong and stable capsule shells. These capsules can protect the drug inside and release it at the appropriate site in the digestive tract.
2. Food industry
Thickening agent:
Function: In food products such as sauces, dressings, and puddings, Hypromellose E6 can increase the viscosity of the product. For example, in a tomato sauce, it helps to give the sauce a more consistent, thick texture, preventing it from being too runny. This thickening effect also improves the mouthfeel of the food, making it more appealing to consumers.
Emulsifier and stabilizer:
Function: It can help to prevent the separation of oil - in - water or water - in - oil emulsions in food products. In mayonnaise, for instance, Hypromellose E6 helps to keep the oil droplets dispersed in the water - based phase, maintaining the emulsion's stability over time. It also stabilizes foams in products like whipped cream, preventing the collapse of the foam structure.
3. Construction industry
Mortar and grout additives:
Function: When added to mortar and grout, Hypromellose E6 improves workability. It increases the water - retention capacity of the mortar, which is crucial for preventing rapid drying of the mortar during the setting process. This allows the mortar to maintain plasticity for a longer period, making it easier to spread and apply on surfaces. It also enhances the adhesion of the mortar to substrates, improving the bond strength between the mortar and bricks or tiles.
4. Cosmetics and personal care industry
Gel and cream formulation:
Function: Hypromellose E6 is used to thicken cosmetic gels and creams. In a facial gel, for example, it gives the product a suitable consistency, making it easy to apply and spread on the skin. It also helps to keep the various ingredients in the formulation well - dispersed, ensuring a homogeneous product. Additionally, it can form a thin, protective film on the skin, which may have some moisturizing and skin - conditioning effects.
Specifications:
| Composition | C10H10N2O |
| Assay | 99% |
| Appearance | White crystalline powder |
| CAS No. | 879-37-8 |
| Packing | Small and bulk |
| Shelf Life | 2 years |
| Storage | Store in cool and dry area |
| Certification | ISO |
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