| Customization: | Available |
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| CAS No.: | 112965-21-6 |
| Formula: | C27h40o3 |
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Calcipotriene monohydrate (also known as calcipotriol monohydrate, MC 903 monohydrate) is a synthetic vitamin D3 analog with the chemical formula. It is primarily used in the treatment of psoriasis due to its ability to regulate keratinocyte proliferation and differentiation by binding to the vitamin D receptor (VDR)
Calcipotriene monohydrate mimics 1,25-dihydroxyvitamin D3 (calcitriol) but has a lower risk of inducing hypercalcemia. It exerts its effects by:
Binding to VDR, modulating gene expression to reduce keratinocyte hyperproliferation.
Suppressing pro-inflammatory cytokines (e.g., IL-8) in keratinocytes stimulated by IL-17A/IL-222.
Enhancing NK cell activity by upregulating NKp30 expression2.
Psoriasis Treatment
Used topically in creams, ointments, and scalp solutions
Reduces plaque formation and skin scaling38.
Research Applications
Studied for its immunomodulatory effects in autoimmune diseases.
Investigated in cancer research due to VDR-mediated antiproliferative effects
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