| Customization: | Available |
|---|---|
| Antibacterial Type: | Chemical Antibacterial, Natural Antibacterial |
| Applied animal classification: | Aquatic Animals, Livestock, Poultry |
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Triclabendazole is a potent antiparasitic drug that is primarily used to treat fascioliasis, a disease caused by liver flukes, specifically Fasciola hepatica and Fasciola gigantica. It is a benzimidazole derivative with a narrow spectrum of activity, effective against these trematode parasites at all stages of infection .
Chemical Information:
Pharmacodynamics: The exact mechanism of action of triclabendazole is not fully understood but is believed to involve the disruption of the parasite's tegument and the inhibition of microtubule-based processes or adenylate cyclase activity. The drug and its sulfoxide metabolite are absorbed by the parasite, leading to a reduction in the resting membrane potential and the inhibition of tubulin function, protein, and enzyme synthesis necessary for survival .
Pharmacokinetics: After oral administration, triclabendazole is rapidly absorbed, with peak plasma concentrations reached within 2-4 hours. The drug is extensively metabolized in the liver, primarily to the active sulfoxide metabolite, which is thought to contribute significantly to the drug's efficacy. The mean elimination half-life of the sulfoxide metabolite is approximately 11 hours in the fed state .
| ANALYSIS ITEM | SPECIFICATION | RESULT |
| Appearance | White to light cream colored crystalline or amorphous powder, Odorless | White powder |
| Loss on Drying | ≤1.0% | 0.2% |
| Melting Point | 175~176ºC | 175~176ºC |
| Identification | UV,TLC | Complies |
| Related Impurities | ≤2.0% | Complies |
| Assay | ≥98% | 98.7% |
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