| Customization: | Available |
|---|---|
| Antibacterial Type: | Chemical Antibacterial, Natural Antibacterial |
| Applied animal classification: | Aquatic Animals, Livestock, Poultry |
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Specifications:
| ANALYSIS ITEM | SPECIFICATION | RESULT |
| Colour | White | Conforms |
| Content | >98% | 98.5% |
| Heavy Metal Content (Pb) | ≤10 mg/kg | Conforms |
Tiamulin is a semisynthetic derivative of pleuromutilin, a diterpene antibiotic, and is widely used in veterinary medicine for the treatment of various bacterial infections in animals. It is particularly effective against gram-positive bacteria, mycoplasmas, and anaerobes, including Brachyspira hyodysenteriae, which causes swine dysentery .
Mechanism of Action: Tiamulin interferes with protein synthesis in bacteria by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting peptide bond formation and leading to the cessation of bacterial growth .
Pharmacokinetics: When administered orally, tiamulin is well absorbed from the gastrointestinal tract of animals. It is detectable in the blood within 30 minutes after dosing and is widely distributed in the body, with highest levels found in the lungs . The drug is extensively metabolized, with over 20 metabolites identified, some of which possess antibacterial activity .
Usage: Tiamulin is labeled for use in swine to treat swine dysentery and Actinobacillus pleuropneumoniae. It is typically administered as an oral medicated feed or in water. In poultry, it is used for the control of infectious diseases such as mycoplasmal infections . However, it is important to note that tiamulin can interfere with the metabolism of other drugs like monensin and salinomycin, leading to toxicity if administered together.
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