Fisetin CAS 528-48-3 Health Care High Quality

• Customization: Available
• Transport Package: Drum
• Specification: 99%
• Model NO.: 528-48-3
• Origin: China
• Production Capacity: 10000kg/Month

Product Description

Product Description

 

Fisetin is a natural flavonoid found in various fruits and vegetables, including apples, persimmons, grapes, onions, cucumbers, and strawberries. It has gained significant attention for its potential health benefits, particularly its anti-cancer properties.

Mechanisms of Action

1. Anti-Proliferation: Fisetin suppresses DNA synthesis and induces cell cycle arrest, particularly in the G0/G1 phase, thereby inhibiting cancer cell growth.
2. Induction of Apoptosis: It activates caspase enzymes and the mitochondrial pathway, leading to programmed cell death in cancer cells.
3. Anti-Angiogenic Effects: By inhibiting the expression of vascular endothelial (VEGF), fisetin reduces the formation of new blood vessels necessary for tumor growth.
4. Antioxidant Properties: Fisetin neutralizes reactive oxygen species (ROS) and upregulates endogenous antioxidants, protecting cells from oxidative stress.
5. Inhibition of Invasion and Migration: It suppresses the activity of matrix metalloproteinases (MMPs) and disrupts signaling pathways involved in cancer cell metastasis.
6. Enhancement of Chemotherapeutic Effects: Fisetin has been shown to enhance the effectiveness of chemotherapeutic agents, potentially reducing the required doses and associated toxic effects.

Molecular Targets

• VEGF: Key regulator of angiogenesis in cancer cells.
• MAPK: Involved in cell proliferation, apoptosis, and invasion.
• NF-κB: Regulates cellular processes such as proliferation, apoptosis, invasion, and angiogenesis.
• PI3K/Akt/mTOR: Associated with cell survival, proliferation, and chemoresistance in cancer cells.
• Nrf2/HO-1: Plays a role in the cellular response to oxidative stress and detoxification processes.

Bioavailability and Delivery

Fisetin's low water solubility can limit its bioavailability and therapeutic potential. To overcome this, researchers are exploring nanoemulsion and liposomal formulations to improve fisetin's solubility, stability, and absorption, thereby enhancing its anticancer efficacy.

 

Detailed Photos