| Customization: | Available |
|---|---|
| CAS No.: | 13870-90-1 |
| Formula: | C72h99con18o17p |
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Product name: Coenzyme B12
CAS No: 13870-90-1
Coenzyme B12, also known as adenosylcobalamin, is an essential organometallic coenzyme derived from vitamin B12. It contains a corrin ring coordinating a central cobalt ion, linked to an adenosyl group. This coenzyme plays a crucial role in metabolic pathways, particularly in DNA synthesis, fatty acid metabolism, and amino acid conversion. Its unique structure enables radical-based catalytic processes, making it indispensable in various biological functions. Coenzyme B12 deficiency leads to significant health issues, including neurological and hematological disorders.
Application and Effect
Coenzyme B12 is critical for various enzymatic reactions in cellular metabolism. It serves as a cofactor for key enzymes such as methylmalonyl-CoA mutase and L-methionine synthase, which are involved in energy production and the synthesis of essential biomolecules. In these reactions, coenzyme B12 facilitates radical rearrangements, enabling the transformation of methylmalonyl-CoA to succinyl-CoA-a crucial step in the breakdown of odd-chain fatty acids and amino acids. In medical applications, coenzyme B12 is used to treat and prevent vitamin B12 deficiency, which can lead to pernicious anemia and neurological disorders. It is particularly beneficial for patients with malabsorption syndromes or dietary insufficiencies. In clinical research, it plays a role in understanding diseases related to impaired B12 metabolism, such as genetic disorders affecting cobalamin processing. Beyond its biological significance, coenzyme B12 has potential industrial applications. It is explored in biotechnology for biocatalytic processes that require high specificity and efficiency. For instance, its role in carbon-carbon bond formation is studied for developing sustainable chemical synthesis methods. The coenzyme's radical chemistry and versatility make it a valuable tool in advancing both therapeutic approaches and industrial biotechnology.
Specifications:
| Composition | C72H99CoN18O17P |
| Assay | 99% |
| Appearance | Red to dark red solid |
| CAS No. | 13870-90-1 |
| Packing | Small and bulk |
| Shelf Life | 2 years |
| Storage | Store in cool and dry area |
| Certification | ISO. |
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