| Customization: | Available |
|---|---|
| Antibacterial Type: | Chemical Antibacterial, Natural Antibacterial |
| Applied animal classification: | Aquatic Animals, Livestock, Poultry |
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Specifications:
| ANALYSIS ITEM | SPECIFICATION | RESULT |
| Appearance | A White or White-Like Crystalline Powder | A White or White-Like Crystalline Powder |
| Assay | 97.0%~101.0% | 100.0% |
| Loss on Drying | ≤1.0% | 0.4% |
| Identification | A: I.R, B: UV | Conforms |
Amprolium is a coccidiostat used primarily in veterinary medicine for the prevention and treatment of coccidiosis in chickens, turkeys, and other poultry. It is a thiamine (vitamin B1) analogue that competitively inhibits the uptake of thiamine by coccidia parasites, which are responsible for causing coccidiosis. By blocking the parasite's ability to utilize thiamine, amprolium leads to the starvation and death of the parasites.
Mechanism of Action: Amprolium works by mimicking thiamine, competing for transport and uptake by coccidia parasites. The parasite's thiamine transport systems are more sensitive to amprolium than those of the host, which accounts for the species selectivity. However, prolonged high doses can cause thiamine deficiency, particularly in young animals .
Pharmacokinetics: When administered orally to chickens, amprolium has low bioavailability, but the absorbed fraction is widely distributed into the tissues and rapidly eliminated in the urine and feces. It is primarily in the egg yolk when administered to laying hens, and residues can be detected in eggs for 10 days or more after cessation of treatment, depending on the dose and assay sensitivity.
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