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Sodium beta-hydroxy-beta-methylbutyrate (HMB-Na) is a metabolite of the essential amino acid leucine and is commonly used as a dietary supplement to support muscle growth, strength, and recovery. It plays a significant role in various physiological processes, including protein synthesis, muscle mass maintenance, and exercise performance enhancement.
HMB-Na, with the CAS number 67237-06-7, is an odorless, white crystalline powder with a slightly salty taste. It is highly soluble in water, which makes it an effective and bioavailable form for supplementation. The compound has been extensively studied for its potential benefits in both athletic and clinical populations.
In exercise science, HMB-Na is recognized for its ability to reduce muscle catabolism, which is the breakdown of muscle tissue, and to promote anabolism, the building of muscle tissue. This dual action makes it a popular supplement among bodybuilders, athletes, and those engaged in resistance training. HMB-Na is also known to increase the activity of the mammalian target of rapamycin (mTOR) pathway, which is a key regulator of protein synthesis and cell growth.
Clinically, HMB-Na has been studied for its potential to improve muscle mass and strength in elderly individuals and those suffering from muscle-wasting conditions. It has been suggested that HMB-Na could be a therapeutic agent for sarcopenia, the age-related loss of muscle mass and function