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Candesartan is an angiotensin II receptor blocker (ARB) that is used to treat high blood pressure (hypertension) in adults and children who are at least 1 year old. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently. Candesartan is also used in adults to treat certain types of heart failure and to lower the risk of death or hospitalization for heart damage. It is available under the brand name Atacand, among others, and is typically taken once or twice a day in tablet form .
The drug is also used off-label for various conditions, including stroke, diabetic nephropathy, left ventricular hypertrophy, and migraines. Candesartan has been found to be effective in reducing blood pressure and has a similar efficacy to other ARBs and ACE inhibitors. It is often prescribed as monotherapy but is also available in combination with low-dose hydrochlorothiazide, a thiazide diuretic, to enhance its antihypertensive effect .
Candesartan is generally well-tolerated, but potential side effects can include headache, dizziness, high potassium levels, and abnormal kidney function tests. Serious side effects such as an allergic reaction (hives, difficulty breathing, swelling of the face) require immediate medical attention. It is crucial to note that candesartan is a teratogen and is contraindicated during pregnancy, especially in the second and third trimesters, as it can cause injury or death to the unborn baby .
When taking candesartan, it is important to follow all directions provided by the prescribing healthcare provider. The medication should be taken with a full glass of water and can be taken with or without food. If a dose is missed, it should be taken as soon as remembered unless it is close to the time for the next dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be followed
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