| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Simvastatin is a member of the statin class of medications, which are widely prescribed for the management of high cholesterol levels and cardiovascular disease risk reduction. It is a potent and specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the biosynthesis of cholesterol in the liver.
Mechanism of Action: Simvastatin works by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver. By blocking this enzyme, simvastatin reduces the liver's ability to produce cholesterol, leading to a decrease in blood cholesterol levels. This results in a reduction of low-density lipoprotein cholesterol (LDL-C), often referred to as "bad" cholesterol, and an increase in high-density lipoprotein cholesterol (HDL-C), the "good" cholesterol.
Indications: Simvastatin is indicated for the reduction of elevated total cholesterol, LDL cholesterol, and triglyceride levels in patients with primary hypercholesterolemia (including familial hypercholesterolemia) and mixed dyslipidemia. It is also used in the prevention of cardiovascular events in patients with established coronary heart disease, peripheral vessel disease, or other forms of clinical atherosclerosis.
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