D-Mannose CAS 3458-28-4 Sweetener Food Grade Top Quality

• Customization: Available
• CAS No.: 3458-28-4
• Formula: C6h12o6
• Model NO.: CAS 3458-28-4
• EINECS: 222-392-4
• Packaging Material: Paper
• Storage Method: Normal
• Shelf Life: >12 Months
• Nutrient Composition: Mineral
• Resource: Natural
• The content of active substances: ＞90%
• Transport Package: Drum
• Specification: 99%
• Trademark: PUYER
• Origin: China
• Production Capacity: 100000kg/Month

Product Description

Product Description

Product name: D-Mannose
CAS No: 3458-28-4

Mannose is a sugar with the formula HOCH2(CHOH)4CHO. It is one of the monomers of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylation are associated with mutations in enzymes involved in mannose metabolism.

Mannose is not an essential nutrient; it can be produced in the human body from glucose, or converted into glucose. Mannose provides 2-5 kcal/g. It is partially excreted in the urine.

Mannose (D-mannose) is used as a dietary supplement to prevent recurrent urinary tract infections (UTIs). As of 2022, one review found that taking mannose was as effective as antibiotics to prevent UTIs, while another review found that clinical trial quality was too low to allow any conclusion about using D‐mannose to prevent or treat UTIs. In 2024, a randomized clinical trial among 598 women with recurrent UTI recruited from primary care settings found the proportion experiencing a medically attended UTI was 51.0% in those taking daily D-mannose over 6 months and 55.7% in those taking placebo, concluding that D-mannose should not be recommended to prevent future episodes of medically attended UTI in women with recurrent UTI in primary care.

Application and Effect

1. Urinary Tract Health

D-Mannose is widely used for the prevention and treatment of urinary tract infections (UTIs). It works by preventing bacteria, particularly Escherichia coli (E. coli), from adhering to the walls of the urinary tract.
E. coli is the most common cause of UTIs. These bacteria have fimbriae (tiny appendages) that allow them to attach to the uroepithelial cells lining the urinary tract. D-Mannose has a similar chemical structure to the receptors on the surface of uroepithelial cells to which E. coli binds. When D-Mannose is present in the urinary tract, the bacteria preferentially bind to it instead of the cells.
As a result, the bacteria are then flushed out of the body during urination. For example, in a clinical - like setting, studies have shown that taking D-Mannose supplements can reduce the recurrence rate of UTIs in women who are prone to such infections.

1. Inflammatory Bowel Disease (IBD) Research

Some research suggests that D-Mannose may have a role in the management of IBD. In the gut, it may help to regulate the immune response and reduce inflammation.
The gut microbiota plays a crucial role in maintaining gut health. D-Mannose can potentially influence the composition of the gut microbiota. It may promote the growth of beneficial bacteria and suppress the growth of harmful bacteria. In animal models of IBD, D-Mannose supplementation has shown some promise in alleviating symptoms such as diarrhea and intestinal inflammation. However, more human - based studies are needed to confirm these effects.

1. Biomedical and Diagnostic Applications

D-Mannose is used in the field of glycobiology research. It is a key component of many glycoproteins and glycolipids. Glycoproteins play important roles in cell-cell recognition, cell signaling, and immune responses.
In diagnostic tests, D-Mannose - conjugated molecules can be used to detect specific antibodies or antigens. For example, in immunoassays, D-Mannose can be attached to a target molecule to improve the specificity and sensitivity of the test for detecting diseases such as certain autoimmune disorders or infectious diseases.

1. Food and Beverage Industry

D-Mannose is used as a sweetener in some food and beverage products. It has a sweet taste, although it is not as sweet as sucrose.
It is also a source of energy. In the body, D-Mannose can be metabolized through the glycolytic pathway, similar to other sugars. However, its metabolism is relatively slow compared to glucose. In sports nutrition, it can potentially provide a more sustained release of energy during physical activities.

Specifications:
 

Composition	C6H12O6
Assay	99%
Appearance	White crystalline powder
CAS No.	3458-28-4
Packing	Small and bulk
Shelf Life	2 years
Storage	Store in cool and dry area
Certification	ISO

 

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