| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Phloridzin is a naturally occurring phytochemical that belongs to the class of dihydrochalcones, which are phenylpropanoids. It is a glucoside of phloretin, a type of flavonoid, and is particularly abundant in the skin of apples, where it contributes to the fruit's bitterness. Phloridzin has been the subject of extensive research due to its potential health benefits and diverse biological activities.
Biosynthesis and Distribution: Phloridzin is synthesized in plants like apple trees (Malus sp.) through a specific biosynthetic pathway involving enzymes such as chalcone synthase and UDP-glucose:phloretin 2′-O-glycosyltransferase. It is distributed in various plant species, with higher concentrations typically found in the bark, leaves, and fruit skin of apple trees. The compound has been used for chemotaxonomic differentiation of rosaceous plant species and as a marker for fraudulent identification in the plant kingdom .
Pharmacological Effects: Phloridzin has been studied for its potential role in managing diabetes, as it inhibits the sodium-glucose cotransporters SGLT1 and SGLT2, which can reduce renal glucose reabsorption and lower blood glucose levels. It also exhibits antioxidant, anti-inflammatory, and anti-cancer properties. Research has shown that phloridzin can improve hyperglycemia in diabetic mice, stimulate melanogenesis, and protect against erythrocyte cell membrane scrambling
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