| Customization: | Available |
|---|---|
| Transport Package: | Drum |
| Specification: | 99% |
|
Still deciding? Get samples of US$ 50/Piece
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of drugs known as Cox-2 inhibitors. It is marketed under the brand names Celebrex and Elyxyb. Celecoxib is used to treat various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain. It is also used to treat juvenile rheumatoid arthritis in children who are at least 2 years old and in the treatment of hereditary polyps in the colon. Elyxyb is specifically used to treat migraine headaches in adults.
Celecoxib works by reducing hormones that cause inflammation and pain in the body. It is taken orally and is rapidly absorbed, reaching peak serum concentration in approximately 3 hours. The drug is extensively metabolized in the liver, primarily by the CYP2C9 enzyme, with less than 3% of the drug being eliminated unchanged. The major routes of excretion for celecoxib are feces and urine.
Celecoxib can increase the risk of fatal heart attack or stroke, and it may also cause stomach or intestinal bleeding, which can be fatal. It is contraindicated in the setting of coronary artery bypass graft (CABG) surgery and should not be used if there is a history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.
The drug should be taken exactly as prescribed, and it is important to inform the doctor of any other medications being taken, as celecoxib can interact with other drugs, including antidepressants, steroid medicine, or medicine to treat or prevent blood clots.
Common side effects of celecoxib may include stomach pain, heartburn, gas, diarrhea, constipation, nausea, and vomiting. More serious side effects can occur and may require immediate medical attention, such as signs of an allergic reaction, severe skin reactions, heart problems, signs of stomach bleeding, liver problems, kidney problems, and low red blood cells (anemia).
Celecoxib has also shown promise in the prevention of cancer and has been used as an adjunct to surgery to reduce the number of adenomatous colorectal polyps in patients with familial adenomatous polyposis (FAP). The drug's pharmacogenomics profile is complex, with genetic factors influencing response to celecoxib and potential to predict variations in response and celecoxib-induced adverse events.
){kind=link}