| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Salcaprozate Sodium (SNAC) is an oral absorption promoter that has been recognized for its potential as a delivery agent for oral forms of heparin and insulin. It is known to enhance passive transcellular permeation across small intestinal epithelia, which is attributed to increased lipophilicity arising from non-covalent macromolecule complexation. This compound has been the subject of research for its ability to improve the absorption of drugs when taken orally, particularly peptides and other macromolecules that typically have low bioavailability when administered through this route.
The mechanism of action of SNAC involves its interaction with the epithelial cells of the small intestine, which may include the opening of tight junctions between cells or the perturbation of the cell membrane to allow for the passage of therapeutic agents. It has been shown to increase the apparent permeability coefficient (Papp) of drugs in vitro, indicating its potential to enhance their absorption in vivo.
In terms of safety, SNAC has been studied for its effects on intestinal tissue, and it has been shown to not cause gross damage to intestinal mucosa in animal and human studies. However, its effects can be influenced by the components of the gastrointestinal fluids, which may attenuate its activity.
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