| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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5-Fluorouracil (5-FU), with the CAS number 51-21-8, is a potent antitumor agent that belongs to the class of antimetabolite drugs. It is a structural analog of the pyrimidine base thymine and is widely used in the treatment of various types of cancer, including gastrointestinal cancers such as colorectal, gastric, pancreatic, esophageal, and hepatic, as well as breast, ovarian, cervical, bladder, and head and neck cancers.
The mechanism of action of 5-FU involves the inhibition of the enzyme thymidylate synthase, which is essential for the synthesis of thymidine, a nucleoside required for DNA replication. By inhibiting this enzyme, 5-FU depletes the cellular pool of thymidine, thereby disrupting DNA synthesis and leading to cell cycle arrest and apoptosis. Additionally, 5-FU can be incorporated into RNA, affecting protein synthesis and further contributing to its cytotoxic effects.
5-FU is typically administered intravenously due to its erratic oral absorption. It is metabolized in the liver and excreted primarily in the form of CO2 and urea. The drug has a short half-life, ranging from 10 to 20 minutes, and its toxicity can be influenced by factors such as dosage, route of administration, and duration of therapy.
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