| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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1-Hydroxybenzotriazole hydrate, also known as HOBt hydrate, is a white crystalline compound commonly used as a coupling agent in peptide synthesis. Its chemical formula is C6H5N3O·H2O, with a molar mass of approximately 153.14 g/mol. The compound has a melting point of 155-158°C (lit.) and is slightly soluble in water. It is typically stored at room temperature in an inert atmosphere and away from light to prevent decomposition.
HOBt hydrate is often used in organic synthesis to facilitate the formation of amide and ester bonds, particularly in the synthesis of peptides and other biologically active molecules. It is known to reduce racemization during peptide bond formation when used with carbodiimide coupling reagents.
The compound is also used as a protecting agent for peptides and in the synthesis of the pharmaceutical compound Ubenimex, which is used for the treatment of certain types of cancer. In addition to its applications in pharmaceuticals, HOBt hydrate is also utilized as a metal surface treatment agent.
When handling 1-Hydroxybenzotriazole hydrate, it is important to follow proper safety procedures, as it can be hygroscopic and may pose certain hazards. It should be stored away from heat and ignition sources.
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