| Customization: | Available |
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| CAS No.: | 107667-60-7 |
| Formula: | C9h12n4o3zn |
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| Product names | Zinc Carnosine;Polaprezinc |
| CAS No | 107667-60-7 |
Zinc Carnosine is a complex formed by the chelation of zinc ions with L-carnosine, a dipeptide composed of β-alanine and L-histidine. This compound has a molecular weight of approximately 288.59. It is available as a white to off-white powder, with good solubility in water under acidic conditions.
Mechanism of Action
Antioxidant Effects: Zinc Carnosine acts as a potent scavenger of free radicals, reducing oxidative stress in the gastrointestinal tract.
Anti-inflammatory Properties: It helps modulate the immune response and reduce inflammation, which is beneficial for conditions like gastritis and inflammatory bowel disease (IBD).
Mucosal Protection and Repair: Zinc Carnosine promotes the repair of damaged mucosal tissues and enhances the integrity of the gastrointestinal barrier. It specifically targets damaged areas, releasing zinc locally to support healing.
Anti-ulcer Activity: It has been shown to be effective in treating peptic ulcers and preventing recurrence.
Clinical Applications
Gastric Ulcers: Zinc Carnosine has been used to accelerate the healing of gastric ulcers and improve symptoms. For example, in an 8-week clinical trial, patients receiving 150 mg of Zinc Carnosine daily showed significant improvement in ulcer symptoms.
Inflammatory Bowel Disease: It has demonstrated potential in managing conditions like Crohn's disease and ulcerative colitis by reducing inflammation and maintaining gut barrier integrity.
Leaky Gut Syndrome: Zinc Carnosine helps maintain the structural integrity of tight junctions in the intestinal lining, potentially reducing intestinal permeability.
Support for Chemotherapy and Radiation Therapy: It has been studied for its protective effects on the gastrointestinal mucosa during chemoradiotherapy.
Safety and Dosage
Zinc Carnosine is generally considered safe and well-tolerated. The typical dosage for therapeutic effects ranges from 75 mg to 150 mg per day, depending on the specific condition being treated.
Conclusion
Zinc Carnosine is a promising compound for supporting gastrointestinal health due to its antioxidant, anti-inflammatory, and mucosal protective properties. It has shown efficacy in treating and preventing various gastrointestinal disorders and is a subject of ongoing research to explore its full potential.
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