| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat the symptoms of osteoarthritis and rheumatoid arthritis. It is a cyclooxygenase inhibiting agent that is well established for managing musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Mechanism of Action: Piroxicam works by reducing hormones that cause inflammation and pain in the body. It is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. It also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Pharmacokinetics: Piroxicam is well absorbed following oral administration. It has a volume of distribution of 0.14 L/kg and a half-life ranging from 30 to 86 hours. The drug and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. However, a substantial portion of piroxicam elimination occurs by hepatic metabolism. Piroxicam is excreted into human milk.
Adverse Effects: Common side effects of Piroxicam include gastrointestinal issues such as nausea, and an increased risk of bleeding. It can also cause headaches, dizziness, and allergic reactions like skin rashes. More serious side effects can include ulcers, bleeding in the stomach or intestines, and liver or kidney toxicity.
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