| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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L-Homophenylalanine (L-Hph), also known as (2S)-2-amino-4-phenylbutanoic acid, is a non-proteinogenic amino acid that is an analogue of L-phenylalanine. It is characterized by having a 2-phenylethyl side-chain instead of a benzyl side-chain, which distinguishes it from L-phenylalanine. L-Homophenylalanine is a significant chiral building block used in the synthesis of various pharmaceutical drugs, particularly angiotensin-converting enzyme (ACE) inhibitors, which are utilized in the treatment of hypertension and heart failure, and the novel proteasome inhibitor carfilzomib, used for treating multiple myeloma.
The production of L-Homophenylalanine can be achieved through both chemical and biocatalytic methods. Biocatalytic methods are often preferred due to their enantioselectivity and environmentally friendly conditions. One such method involves the use of N-acylamino acid racemase (NAAAR) and l- N-carbamoylase (LNCA) to convert racemic N-acetyl-homophenylalanine (NAc-HPA) to L-Homophenylalanine with high purity and yield.
Research has also focused on the discovery of biosynthetic genes responsible for L-Homophenylalanine synthesis. For instance, scientists have identified genes in the cyanobacterium Nostoc punctiforme PCC73102 that are involved in L-Homophenylalanine production, providing a potential route for microbial production of this important compound.
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