| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Azathioprine is an immunosuppressive drug, classified as an antimetabolite, and is primarily used to prevent rejection in organ transplant patients, particularly those who have received a kidney transplant. It is also used to treat autoimmune diseases such as rheumatoid arthritis and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The drug works by suppressing the immune system, which helps to prevent the body from attacking the transplanted organ or the body's own tissues.
Mechanism of Action: Azathioprine is a prodrug of 6-mercaptopurine and its mechanism of action is not entirely understood. It is thought to inhibit purine synthesis, which is necessary for the production of DNA and RNA, thereby suppressing the growth of immune cells. Additionally, it may induce T-cell apoptosis, which contributes to its immunosuppressive effects.
Dosage and Administration: The dosage of azathioprine varies depending on the patient's medical condition and response to therapy. It is usually taken once or twice a day, with food to reduce gastrointestinal upset. Blood tests are often required to monitor the effects of the drug and to adjust the dosage accordingly.
Side Effects: Common side effects can include nausea, vomiting, diarrhea, and hair loss. More serious side effects can include increased risk of infection due to immunosuppression, liver problems, and a rare but serious brain infection called progressive multifocal leukoencephalopathy (PML).
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