| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Chlorambucil, also known by the brand name Leukeran, is an oral medication classified as an alkylating agent. It is primarily used for the treatment of chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma, and certain types of non-Hodgkin's lymphoma. The drug works by interfering with the DNA of cancer cells, thereby slowing or stopping their growth.
Mechanism of Action: Chlorambucil is a nitrogen mustard derivative that alkylates and cross-links DNA, leading to disruption of nucleic acid function and ultimately inhibiting the growth of cancer cells.
Dosage and Administration: The typical dosage for adults with CLL is 0.1 mg/kg/day for 3-6 weeks, with adjustments based on clinical response and tolerance. It is usually taken once daily, either continuously or intermittently. The drug should be stored in a refrigerator and taken on an empty stomach.
Side Effects: Chlorambucil can cause a range of side effects, including bone marrow suppression, which may lead to anemia, leukopenia, and thrombocytopenia. Other potential side effects include nausea, vomiting, diarrhea, mouth sores, and an increased risk of infections due to immunosuppression. Long-term use may also increase the risk of developing other cancers.
Precautions: Chlorambucil is contraindicated in patients with hypersensitivity to the drug or a history of resistance to it. It is classified as pregnancy category D, indicating that it can harm an unborn baby and should not be used during pregnancy. The drug can also potentially cause infertility.
Interactions: Chlorambucil may interact with other medications, including those that affect the immune system or bone marrow function. It is advised to use caution when taking other medications concurrently, and to inform the healthcare provider of all current medications.
Storage: Chlorambucil tablets should be stored in a refrigerator at 2° to 8°C (36° to 46°F) to maintain their stability.
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