| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclodextrin derivative that has gained significant attention in the pharmaceutical industry due to its versatile applications. It is a modified form of β-cyclodextrin, where hydroxypropyl groups are attached to the hydroxyl groups of the cyclodextrin molecule. This modification enhances the solubility and stability of the complex formed with guest molecules, which is particularly useful in drug delivery systems.
HP-β-CD is known for its ability to form inclusion complexes with a variety of drugs, thereby improving their solubility, bioavailability, and stability. It has a hydrophilic exterior and a hydrophobic central cavity, which allows it to encapsulate hydrophobic drug molecules, forming non-covalent dynamic inclusion complexes. This property is utilized to enhance the solubility of drugs that are otherwise poorly soluble in water, a common issue in the pharmaceutical industry.
In addition to its role as an excipient, HP-β-CD has also been recognized for its potential therapeutic applications. It was granted orphan drug status in 2015 for the treatment of Niemann-Pick type C disease, a rare genetic disorder. Research is ongoing to explore its therapeutic potential for various other disorders.
The degree of substitution (DS) is a critical characteristic that influences the complexation ability of HP-β-CD. The DS refers to the number of hydroxypropyl groups attached to the cyclodextrin molecule, and it can significantly affect the complexation efficiency. The correlation between DS and complexation is dependent on the molecular weight of the guest drug, with different DS values being optimal for different drugs.
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