| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Methotrexate CAS 59-05-2 Health Care High Quality
Methotrexate is a medication that is primarily used as an anti-metabolite in chemotherapy and as an immunosuppressant in autoimmune diseases. It is a folic acid antagonist that has been approved by the FDA for the treatment of various conditions, including rheumatoid arthritis, polyarticular-course juvenile rheumatoid arthritis, psoriasis, and certain types of cancer such as leukemia, breast cancer, and non-Hodgkin's lymphoma .
The mechanism of action of methotrexate involves the inhibition of the enzyme dihydrofolate reductase, which is essential for the synthesis of tetrahydrofolate, a carrier of one-carbon units required for the synthesis of purines and pyrimidines. By inhibiting this enzyme, methotrexate interferes with DNA and RNA synthesis, thereby inhibiting cell proliferation .
Methotrexate is available in various forms, including tablets, injectable solutions, and oral solutions. It is typically administered orally on a weekly basis for conditions like rheumatoid arthritis and psoriasis. For cancer treatment, it may be given intramuscularly, intravenously, intrathecally, or subcutaneously .
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