| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Enalapril maleate is an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension, heart failure, and asymptomatic left ventricular dysfunction. It works by suppressing the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that, after ingestion, is rapidly biotransformed into its active metabolite, enalaprilat, which is responsible for the pharmacological actions of enalapril.
The active metabolite, enalaprilat, competitively inhibits ACE, thereby hindering the production of angiotensin II, a key component of the renin-angiotensin-aldosterone system that promotes vasoconstriction and renal reabsorption of sodium ions in the kidneys. This action ultimately leads to a reduction in blood pressure and blood fluid volume. Enalapril is commonly marketed under the trade name Vasotec and was first approved by the FDA in 1985.
The chemical formula for enalapril maleate is C24H32N2O9, with a molecular weight of 492.519. It appears as a white to off-white crystalline powder and is slightly hygroscopic. It is soluble in methanol, slightly soluble in water, and practically insoluble in chloroform. The common dosage for enalapril maleate is 10-40mg daily, depending on the condition being treated and the patient's response to therapy.
Enalapril maleate should be stored in a light-protected and sealed container. It is available in various pharmaceutical forms, including tablets and capsules, and is usually taken orally. The drug is contraindicated in patients with a history of hypersensitivity to enalapril or other ACE inhibitors, in those with bilateral renal artery stenosis, and during pregnancy and lactation due to potential risks to the fetus and infant.
Adverse reactions may include dizziness, headache, fatigue, cough, and in some cases, a potentially serious condition called angioedema, which can cause swelling of the face, lips, tongue, throat, or other parts of the body. Patients should be advised to seek immediate medical attention if they experience any signs of angioedema.
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