Cyproheptadine Hydrochloride Sesquihydrate CAS 41354-29-4 Health Care

• Customization: Available
• Transport Package: Drum
• Specification: 99%
• Model NO.: 41354-29-4
• Origin: China
• Production Capacity: 10000kg/Month

Product Description

Product Description

 

Cyproheptadine hydrochloride sesquihydrate, known by the chemical name 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine hydrochloride hydrate, is a medication with antihistamine, anti-serotonin, and mild anticholinergic properties. It is commonly used to treat conditions such as allergies, itching, and certain gastrointestinal disorders.

Pharmacological Action: Cyproheptadine exhibits its effects primarily by acting as a histamine H1 receptor antagonist, which helps in reducing allergic symptoms. It also has serotonin antagonist activity, which can be useful in treating conditions like migraines where serotonin is involved. The mild anticholinergic effects can help reduce symptoms like excessive secretions and spasms in the gastrointestinal tract.

Clinical Uses:

• Allergic Rhinitis: It is used to alleviate symptoms such as sneezing, itching, and runny nose.
• Urticaria and Angioedema: Cyproheptadine can help reduce itching and swelling associated with hives and angioedema.
• Gastrointestinal Disorders: It can be used to manage symptoms of gastrointestinal conditions where excessive histamine is a factor, such as in some cases of inflammatory bowel disease.
• Appetite Stimulation: Due to its effect on the hypothalamus, cyproheptadine can increase appetite, which can be beneficial in conditions where weight gain is desired.

Pharmacokinetics: Cyproheptadine is well absorbed after oral administration, with peak plasma concentrations typically reached within 2 to 3 hours. It is metabolized in the liver and excreted primarily in the urine.

Safety and Precautions:

• It should be used with caution in patients with a history of seizures due to its potential to lower the seizure threshold.
• Patients with urinary retention, gastrointestinal obstruction, or a history of angle-closure glaucoma should avoid using cyproheptadine.
• The safety of cyproheptadine in pregnancy and breastfeeding has not been established, so its use is not recommended in these populations.

 

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