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N-Acetyl-L-Glycine, with the chemical name 2-(Acetylamino)acetic acid, is an amino acid derivative known for its role as an intermediate in the biosynthesis of certain neurotransmitters and as a potential therapeutic agent for various conditions . It is also referred to by several synonyms, including Acetamidoacetic acid, Acetylglycine, and Glycine, N-acetyl- .
This compound has a molecular weight of approximately 117.1 and a melting point of around 206°C. It is soluble in water, with a solubility of 2.7 g/100 mL at 15°C, and is also soluble in alcohol and slightly soluble in acetone, but insoluble in ether and benzene .
N-Acetyl-L-Glycine is used in scientific research and as a pharmaceutical intermediate. It can be synthesized through the acetylation of glycine with acetic anhydride, resulting in a crystalline product that is an important building block for the synthesis of various organic compounds .
In terms of safety, N-Acetyl-L-Glycine is classified as an irritant, with specific hazard statements indicating that it may cause irritation to the skin (Skin Irrit. 2) and eyes (Eye Irrit. 2A), as well as specific target organ toxicity of a single exposure (STOT SE 3) .
Furthermore, N-Acetyl-L-Glycine has been identified in the context of metabolomics studies, where it is associated with certain diseases such as colorectal cancer, indicating its potential role as a biomarker or in disease metabolism . It is also involved in the detoxification process in mammals, where it forms conjugates with aromatic amino acids as part of the xenobiotic detoxification system .