| Customization: | Available |
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| CAS No.: | 55-22-1 |
| Formula: | C6h5no2 |
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Product name: Isonicotinic Acid
CAS No: 55-22-1
Isonicotinic acid is a derivative of nicotinic acid (niacin), with a carboxyl group (-COOH) located at the 2-position on the pyridin ring. It is a colorless to pale yellow crystalline compound that is soluble in water and alcohol. Isonicotinic acid plays an important role in the synthesis of pharmaceutical compounds, particularly in the preparation of tuberculosis drugs. The structure of isonicotinic acid, which includes the pyridin ring and carboxyl group, allows for a wide range of chemical modifications, making it a valuable intermediate in medicinal chemistry.
Application and Effect
Isonicotinic acid is primarily known for its use as a key precursor in the synthesis of anti-tuberculosis (TB) drugs, most notably isoniazi which is one of the most widely used first-line drugs in the treatment of tuberculosis, and its synthesis relies heavily on isonicotinic acid as a building block. The compound's ability to act as a nucleophile in various reactions makes it useful in creating derivatives that target bacterial enzymes, especially those involved in the biosynthesis of mycolic acids, which are essential for the integrity of the mycobacterial cell wall. Beyond its role in the production of TB medications, isonicotinic acid is also used in the synthesis of other bioactive compounds, including antimalarial drugs and certain anticancer agents. Due to its pyridin structure, it can also be used as a ligand in coordination chemistry, forming complexes with metals for catalysis and other chemical reactions. The carboxyl group on the isonicotinic acid molecule allows for the formation of esters, amides, and other derivatives, which are often used to enhance the pharmacological properties of the parent compound. Isonicotinic acid derivatives have shown promise in modulating various biological pathways, including those involved in neuroprotection and immune modulation. In addition, isonicotinic acid is used in chemical research and is a valuable reagent in organic synthesis, particularly in the preparation of functionalized pyridin compounds for drug discovery and development. Given its critical role in pharmaceutical applications, proper handling and safety measures should be followed when working with isonicotinic acid to avoid any health risks associated with its reactivity and biological activity.
Specifications:
| Composition | C6H5NO2 |
| Assay | 99% |
| Appearance | Yellow to tan powder |
| CAS No. | 55-22-1 |
| Packing | Small and bulk |
| Shelf Life | 2 years |
| Storage | Store in cool and dry area |
| Certification | ISO. |
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