Product Description
Creatine Methyl Ester is a derivative of creatine that has been esterified with a methyl group. This modification may influence its solubility and potentially its absorption in the body. Here is an overview of Creatine Methyl Ester, including its product specifications and a comparison with Creatine Monohydrate (CM):
Composition and Structure:
- Creatine Methyl Ester has a molecular formula of C5H11N3O2 and a molecular weight of 145.16 g/mol. It is typically available with a purity of 95% .
Physico-chemical Properties:
- Creatine forms salts with strong acids and can act as a complexing agent. Creatine Methyl Ester HCl, a derivative, is known for its stability and is used in nutrition or as a food additive. It appears as a white or yellowish powder with an assay of ≥95.0%, a loss on drying of 1.0% max, and heavy metal content (as Pb) ≤10ppm .
Bioavailability:
- The bioavailability of creatine supplements refers to their intestinal absorption and utilization by the body's cells and tissues. While no specific data on Creatine Methyl Ester's bioavailability were found, it is worth noting that the bioavailability of different creatine forms can vary, and some may result in slightly different kinetics of plasma creatine absorption .
Stability:
- Creatine Methyl Ester, like other creatine esters, may be marketed with claims of improved stability. However, studies have shown that some creatine esters, including Creatine Ethyl Ester, can be less stable than CM, which is known for its high stability .
Regulatory Status:
- The regulatory status of various forms of creatine, including esters, can be uncertain in many global markets. In the USA, for example, Creatine Monohydrate is the only form of creatine officially approved or accepted in key markets, while other forms' legal status is ambiguous .
Considerations for Use:
- When selecting a creatine supplement, considerations include bioavailability, efficacy, safety, and regulatory status. Creatine Methyl Ester, like other novel forms of creatine, may be marketed with claims of improved attributes, but it is essential to review specific product literature and scientific studies for detailed understanding and verification.
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