Customization: | Available |
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CAS No.: | 1228558-05-1 |
Formula: | N/a |
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Palmitoyl Tetrapeptide-3 is a synthetic peptide that has been developed for its potential use in skincare products. It is a fragment of the extracellular matrix protein thrombospondin-1 (TSP-1) and is designed to mimic its effects, particularly in increasing the activity of the growth facto TGFβ (Transforming Growth Facto beta). TGFβ is known to play a crucial role in cell regulation, proliferation, and tissue repair, which makes Palmitoyl Tetrapeptide-3 an attractive ingredient for anti-aging treatments.
The sequence of Palmitoyl Tetrapeptide-3 is specifically designed to stimulate the production of Type I and Type III collagen by dermal fibroblasts. This stimulation is believed to occur through the peptide's ability to locally increase TGFβ activity, which in turn promotes collagen synthesis. In animal models and human dermal fibroblast cell culture tests, the peptide has shown positive effects on wound healing and is thought to be involved in the post-natal development of skin structures .
In terms of its efficacy, Palmitoyl Tetrapeptide-3 has been reported to be roughly 3.5 times more effective at reducing the appearance of wrinkles than a placebo. In vivo results from a cream formulation containing the peptide have demonstrated a dose-dependent wrinkle reduction, indicating that the peptide's concentration can be adjusted to achieve varying degrees of skin improvement .