| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Alpha Methyldopa Sesquihydrate, also known as L-Methyldopa Sesquihydrate, is an antihypertensive drug used to treat high blood pressure. It is a prodrug that requires biotransformation to an active metabolite for therapeutic effects. The active form of methyldopa is L-α-methyldopa, which works by binding to alpha-2 adrenergic receptors in the central nervous system, leading to the inhibition of adrenergic neuronal outflow and reduction of vasoconstrictor adrenergic signals, thereby lowering blood pressure.
Methyldopa sesquihydrate has a molecular formula of C10H13NO4 and a molecular weight of approximately 211. It is characterized by a melting point of over 300°C and is highly soluble in water. The drug is absorbed from the gastrointestinal tract, with an average bioavailability of about 25%. It is metabolized in the liver and excreted primarily in the urine, with a plasma half-life of about 105 minutes.
Common side effects of methyldopa include drowsiness, dry mouth, and orthostatic hypotension. It is particularly useful in certain patient populations, such as pregnant women and patients with renal insufficiency, due to its unique mechanism of action and safety profile in these groups.
Methyldopa is available in various pharmaceutical forms, including tablets and injectable solutions, and is often prescribed as monotherapy or in combination with other antihypertensive agents, such as hydrochlorothiazide.
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