| Customization: | Available |
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| CAS No.: | 7177-48-2 |
| Formula: | C16h25n3o7s |
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Ampicillin Trihydrate
Chemical Name: (2S,5R,6R)-6-[(2R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
Molecular Weight: 403.45 g/mol
Ampicillin trihydrate is a semi-synthetic penicillin antibiotic derived from the penicillin nucleus, 6-aminopenicillanic acid. It is the trihydrate form of ampicillin, meaning it contains three molecules of water per molecule of ampicillin. It appears as a white or almost white crystalline powder, slightly soluble in water and practically insoluble in organic solvents.
Ampicillin trihydrate is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including Escherichia coli, Haemophilus influenzae, Salmonella, Shigella, and Streptococcus species.
Respiratory infections (e.g., bronchitis, pneumonia)
Urinary tract infections (UTIs)
Gastrointestinal infections (e.g., typhoid, bacterial enteritis)
Meningitis (in combination with other antibiotics)
Septicemia
Prophylaxis in surgery
Available in oral (capsules, suspension) and parenteral (IV/IM) forms.
Dosage varies based on infection severity, patient age, and renal function.
Common adverse effects include:
Diarrhea
Nausea/vomiting
Skin rash (more frequent in patients with mononucleosis)
Allergic reactions (including anaphylaxis in penicillin-sensitive individuals)
Contraindicated in patients with penicillin hypersensitivity.
Use cautiously in those with renal impairment (dose adjustment may be needed).
May reduce effectiveness of oral contraceptives.
Store in a tight container, protected from moisture and light, at room temperature.
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