Mirtazapine CAS 85650-52-8 High Quality Health Care Products

• Customization: Available
• Condition: Brand New
• Customized: Customized
• Model NO.: CAS 85650-52-8
• Logo Printing: Without Logo Printing
• Type: Health Care
• Group: All
• Certification: MSDS
• Transport Package: Drum
• Specification: 99%
• Trademark: Puyer
• Origin: China
• Production Capacity: 10000kg/Month

Product Description

Product Description

• •  

 

Mirtazapine

Chemical Name:
(±)-2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Molecular Weight: 265.35 g/mol
CAS Number: 85650-52-8 12

Drug Class & Mechanism of Action

• Class: Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)

• Mechanism:

  • Blocks α2-adrenergic autoreceptors, increasing norepinephrine (NE) release 

  • Enhances 5-HT1A-mediated serotonergic transmission while antagonizing 5-HT2 and 5-HT3 receptors, improving mood and reducing anxiety 

  • Strong H1-histamine receptor antagonism causes sedation and weight gain 

Clinical Uses

1. Major Depressive Disorder (MDD): First-line treatment for depression, particularly in patients with insomnia or weight loss

2. Generalized Anxiety Disorder (GDA): Off-label use due to its anxiolytic effects 

3. Insomnia: Low doses (7.5-15 mg) are highly sedating 

4. Appetite Stimulation: Used in cachexia (e.g., cancer/AIDS-related weight loss) 

Pharmacokinetics

• Absorption: Rapid oral absorption (~80% bioavailability) 

• Metabolism: Hepatic, primarily via CYP3A4, CYP2D6, and CYP1A2 

• Half-life: 20-40 hours (longer in elderly patients) 

• Excretion: Renal (75%) and fecal (15%) 

Dosage & Administration

• Starting Dose: 15 mg once daily at bedtime 

• Maintenance Dose: 15-45 mg/day (max 45 mg) 

• Special Populations:

  • Elderly: Lower initial dose (7.5-15 mg) 

  • Hepatic/Renal Impairment: Dose reduction recommended 

Side Effects

• Common: Sedation, increased appetite, weight gain, dry mouth, dizziness 

• Serious (Rare):

  • Agranulocytosis (monitor WBC if fever/sore throat occurs) 

  • Serotonin syndrome (if combined with other serotonergic drugs) 

  • QT prolongation (caution in cardiac patients)

 

Detailed Photos