| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Inositol hexanicotinate, also known as inositol hexaniacinate or inositol nicotinate, is the hexanicotinic acid ester of meso-inositol . This compound consists of six molecules of nicotinic acid (niacin) with an inositol molecule at the center, serving as a source of niacin, which is a form of vitamin B3 essential for human nutrition . Inositol hexanicotinate is absorbed into the bloodstream and then hydrolyzed, resulting in the release of free nicotinic acid and inositol. The metabolic process is slow, with serum levels of nicotinic acid peaking approximately 6-10 hours after ingestion .
As a dietary supplement, inositol hexanicotinate offers benefits such as endothelium-dependent vasodilation, which improves blood flow, particularly in conditions where blood flow is compromised . It is often prescribed in Europe for the symptomatic relief of Raynaud's phenomenon and severe intermittent claudication, with common doses ranging from 3 to 4 grams per day . The compound is also recognized for its "no-flush" effect, as the flushing side effect associated with niacin is less likely to occur with inositol hexanicotinate due to its slow-release nature .
In terms of safety, inositol hexanicotinate has been shown to be well-tolerated with no adverse effects observed in clinical trials up to 4000 mg daily for 3 months . It is considered a safer alternative to traditional niacin supplementation, as it is virtually free of the side effects associated with niacin therapy, such as flushing and pruritus . Furthermore, it has been studied for its potential effectiveness in treating hyperlipidemia, Raynaud's disease, and intermittent claudication
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