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1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid is a heterocyclic compound with the molecular formula C9H6N2O2 and a molecular weight of 178.16 g/mol. This compound belongs to the family of pyrazolo[4,3-b]pyridines, which are known for their diverse synthetic methods and wide range of biomedical applications .
As a heterocyclic compound, 1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid can exist in different tautomeric forms, which may influence its chemical properties and reactivity. The synthesis of such compounds typically involves the fusion of a pyrazole ring with a pyridine ring, and various substituents can be present at different positions on the molecule, leading to a broad range of possible structures and functionalities .
In terms of synthetic approaches, the formation of a pyridine ring onto an existing pyrazole or vice versa is a common strategy. The substituents at various positions of the pyrazolo[4,3-b]pyridine core can be modified to achieve different biological activities, making these compounds valuable in drug discovery and development .
Biomedically, pyrazolo[4,3-b]pyridines have been explored for their potential as antitumor, anti-inflammatory, and nervous system agents. They have shown activity against a range of biological targets, including kinases, proteases, and receptors, which has led to their consideration in the treatment of various diseases such as cancer, inflammation, and neurological disorders