| Customization: | Available |
|---|---|
| Transport Package: | Drum |
| Specification: | 99% |
|
Still deciding? Get samples of US$ 50/Piece
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
Ciclopirox olamine, also known as ciclopirox ethanolamine, is a synthetic antifungal agent with a broad spectrum of activity. It is effective against dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative pathogenic species. In addition to its antifungal properties, ciclopirox olamine has also been found to possess anticancer and anti-inflammatory effects.
Mechanism of Action: Ciclopirox olamine works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane, which leads to the disruption of the cell membrane and ultimately results in cell death.
Pharmacokinetics: When applied topically, ciclopirox olamine has good permeability through the skin and has been shown to penetrate the stratum corneum, reaching the site of infection effectively.
Clinical Uses: It is commonly used in the treatment of various superficial mycoses, including athlete's foot, jock itch, and ringworm. It is also used in the management of seborrheic dermatitis and other skin conditions.
Pharmacological Research: In vitro studies have shown that ciclopirox olamine can inhibit the proliferation and angiogenesis of human umbilical vein endothelial cells (HUVECs). It has also demonstrated antitumor activity in certain cancer cell lines, suggesting potential uses in cancer therapy.
Safety and Side Effects: Ciclopirox olamine is generally well-tolerated, with minimal side effects. However, as with any medication, it can cause local skin irritation in some individuals.
Storage and Stability: The compound should be stored at room temperature, away from moisture, and protected from light. It is stable under normal conditions but may degrade over time if not stored properly.
){kind=link}