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Ezetimibe is a medication primarily used to lower cholesterol levels in individuals with high blood cholesterol. It works by inhibiting the absorption of cholesterol from the intestines, which reduces the amount of cholesterol delivered to the liver. This mechanism leads to a decrease in total cholesterol, low-density lipoprotein (LDL) cholesterol (often referred to as "bad cholesterol"), and other fatty substances in the blood.
Ezetimibe is indicated for:
It can be used alone or in combination with other cholesterol-lowering medications, such as statins (e.g., simvastatin) or fenofibrate, to enhance cholesterol-lowering effects .
Ezetimibe is typically taken as a 10 mg oral tablet once daily, with or without food. It is important to take it at the same time each day to maintain consistent levels in the bloodstream. If taking bile acid sequestrants, ezetimibe should be administered 2 hours before or 4 hours after these medications to avoid interactions .
Common side effects include:
Serious side effects can include allergic reactions, liver damage, and muscle problems such as myopathy or rhabdomyolysis, which can lead to kidney damage
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