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Chemical Name:
(±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine hydrochloride
Molecular Weight: 345.79 g/mol
CAS Number: 56296-78-7
Class: Selective Serotonin Reuptake Inhibitor (SSRI)
Mechanism: Potently inhibits the serotonin transporter (SERT), blocking presynaptic reuptake of serotonin (5-HT) and increasing extracellular 5-HT levels in the brain, which alleviates depressive symptoms
Major Depressive Disorder (MDD): First-line treatment for depression, with efficacy comparable to tricyclic antidepressants but better tolerability
Obsessive-Compulsive Disorder (OCD): Reduces intrusive thoughts and compulsive behaviors
Bulimia Nervosa: Decreases binge-eating and purging behaviors (60 mg/day dose)
Absorption: Well-absorbed orally; food does not affect bioavailability
Metabolism: Hepatically metabolized to active metabolite norfluoxetine (half-life: 4-16 days) via CYP2D6/CYP3A4
Half-life: 4-6 days (fluoxetine); norfluoxetine prolongs action
Excretion: Primarily renal (80%)
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