| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Buspirone hydrochloride is a medication classified as an antianxiety agent and is chemically unrelated to benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. It is used primarily for the management of anxiety disorders or for the short-term relief of symptoms of anxiety. The drug is particularly indicated for generalized anxiety disorder (GAD) and is effective in relieving anxiety even when coexisting depressive symptoms are present.
The mechanism of action of buspirone is not fully established, but it is known to have a high affinity for serotonin (5-HT1A) receptors and moderate affinity for brain D2-dopamine receptors. It does not have significant affinity for benzodiazepine receptors and does not affect GABA binding, which distinguishes it from typical benzodiazepine anxiolytics. Buspirone does not exert anticonvulsant or muscle relaxant effects and lacks the prominent sedative effect associated with more typical anxiolytics.
Pharmacokinetically, buspirone is rapidly absorbed and undergoes extensive first-pass metabolism. It is primarily metabolized by oxidation, mediated by cytochrome P450 3A4 (CYP3A4), resulting in several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine (1-PP). The average elimination half-life of unchanged buspirone after single doses is about 2 to 3 hours.
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