| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Doxazosin Mesylate is a medication belonging to the class of selective alpha-1 adrenergic receptor antagonists. It is primarily used in the treatment of hypertension (high blood pressure) and benign prostatic hyperplasia (BPH), commonly known as an enlarged prostate.
Mechanism of Action: Doxazosin Mesylate works by selectively blocking the alpha-1 receptors in the smooth muscle of blood vessels and the prostate, leading to vasodilation and reduced resistance in blood vessels, which lowers blood pressure. In the prostate, it relaxes the muscles to improve urine flow in patients with BPH.
Pharmacokinetics: The drug is well absorbed after oral administration, with peak plasma concentrations occurring within 2 to 6 hours. It is highly protein-bound (approximately 98%) and has a half-life of 19 to 22 hours. Doxazosin Mesylate is extensively metabolized in the liver, with the majority of the metabolites excreted in feces, and a smaller portion in urine.
Dosage and Administration: The usual starting dose for hypertension is 1 mg once daily, which can be gradually increased to a maximum of 16 mg per day, depending on the patient's response and tolerance. For BPH, the starting dose is typically 1 mg once daily, with the dose being adjusted based on individual response.
Adverse Effects: Common side effects include dizziness, headache, fatigue, postural hypotension, and nasal congestion. Less common but more serious side effects can include syncope (fainting), priapism (painful prolonged erection), and ejaculatory disturbances.
Contraindications: Doxazosin Mesylate is contraindicated in patients with a history of hypersensitivity to the drug or any of its components, recent myocardial infarction, and those with gastrointestinal obstruction or severe liver impairment.
Drug Interactions: It is important to note that Doxazosin Mesylate can interact with other medications, including antihypertensives, vasodilators, and other drugs that can cause hypotension. It may also interact with drugs that are metabolized by the liver, potentially affecting their clearance.
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