| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Candesartan cilexetil is an angiotensin II receptor blocker (ARB) that is used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and to delay the progression of diabetic nephropathy. It is administered orally and is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure-increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy, and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction, and coronary artery disease.
The drug is generally well-tolerated, with common side effects including back pain, dizziness, upper respiratory tract infection, and rhinitis. It is highly bound to plasma proteins and has a half-life of approximately 9 hours. Candesartan cilexetil is contraindicated in patients who are hypersensitive to candesartan and should not be co-administered with aliskiren in patients with diabetes. It is important to note that the use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase fetal and neonatal morbidity and death.
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