Product Description
Product name: Glucoraphanin
CAS No: 21414-41-5
Glucoraphanin is a glucosinolate found in broccoli, mustard and other cruciferous vegetables. Glucoraphanin is converted to sulforaphane by the enzyme myrosinase. In plants, sulforaphane deters insect predators and acts as a selective antibiotic.
Glucoraphanin is derived from dihomomethionine, which is methionine chain-elongated twice. The sulfinyl group is chiral, and has R absolute configuration. The stereochemistry is set when an oxygen atom added to 4-methylthiobutylglucosinolate by a flavin monooxygenase.
Application and Effect
- Cancer prevention and health benefits
Glucoraphanin is a precursor of sulforaphane. Sulforaphane has been extensively studied for its potential anti - cancer properties. It can induce phase II detoxification enzymes in the body. These enzymes help to neutralize and eliminate harmful chemicals and carcinogens. For example, in the liver, sulforaphane derived from glucoraphanin can increase the activity of glutathione S - transferases (GSTs), which play a crucial role in detoxifying a wide range of electrophilic toxins and reactive oxygen species.
It may also have a role in preventing the development of certain cancers such as prostate, breast, and lung cancers. In prostate cancer cells, sulforaphane can inhibit cell growth and induce apoptosis (programmed cell death). In breast cancer, it can modulate estrogen - related pathways and reduce the risk of cancer cell proliferation.
- Anti - inflammatory effects
Glucoraphanin - derived sulforaphane can suppress the production of pro - inflammatory cytokines. It can inhibit the activation of nuclear factor - kappa B (NF - κB), a key transcription factor involved in the regulation of inflammatory responses. By reducing the levels of inflammatory mediators like interleukin - 1β (IL - 1β), interleukin - 6 (IL - 6), and tumor necrosis factor - alpha (TNF - α), it can help in alleviating chronic inflammatory conditions such as arthritis and inflammatory bowel disease.
- Cardiovascular health
It may contribute to cardiovascular health. Sulforaphane can improve endothelial function. The endothelium is the inner lining of blood vessels, and its proper function is essential for maintaining normal blood pressure and preventing atherosclerosis. By enhancing endothelial - dependent vasodilation, it can help to lower blood pressure and reduce the risk of cardiovascular diseases.
Glucoraphanin can also reduce oxidative stress in the cardiovascular system. Oxidative stress is a major factor in the development of heart disease, and by scavenging free radicals and reducing lipid peroxidation, it helps to protect the heart and blood vessels.
- Neurological benefits
There is evidence that sulforaphane from glucoraphanin can have neuroprotective effects. It can help to reduce oxidative damage and inflammation in the brain. In neurodegenerative diseases such as Alzheimer's and Parkinson's, it may play a role in protecting neurons from damage. For example, it can enhance the activity of antioxidant enzymes in the brain and reduce the accumulation of amyloid - beta plaques (in the case of Alzheimer's disease), which are thought to contribute to the progression of the disease.
- Use in the food industry
Glucoraphanin - rich sources such as broccoli and other cruciferous vegetables are used in the food industry to develop functional foods. These are foods that not only provide basic nutrition but also offer health - promoting benefits. For example, broccoli sprouts, which are a concentrated source of glucoraphanin, can be added to salads, sandwiches, or used as an ingredient in health - focused food products to increase the intake of this beneficial compound.
Specifications:
| Composition |
C12H23NO10S3 |
| Assay |
99% |
| Appearance |
White to light yellow powder |
| CAS No. |
21414-41-5 |
| Packing |
Small and bulk |
| Shelf Life |
2 years |
| Storage |
Store in cool and dry area |
| Certification |
ISO |
Detailed Photos
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