| Customization: | Available |
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| Transport Package: | Cartons/Drums |
| Specification: | white tablet |
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N-Acetyl-L-Aspartic Acid (NAA) is a significant amino acid derivative primarily associated with the metabolism of the vertebrate brain. It is one of the most concentrated amino acids in the brain and is synthesized and stored predominantly in neurons, although it cannot be hydrolyzed in these cells. NAA is dynamically regulated and turns over more than once daily through a continuous efflux and intercompartmental cycling between neurons and oligodendrocytes, which are the cells responsible for producing the myelin sheath in the central nervous system .
The exact functional role of NAA in brain metabolism remains a subject of scientific inquiry. It has been proposed to serve multiple functions, including acting as a neuronal osmolyte involved in brain fluid balance, a source of acetate for lipid and myelin synthesis, a precursor for the synthesis of the neuronal dipeptide N-acetylaspartylglutamate, and potentially playing a role in energy production from the amino acid glutamate in neuronal mitochondria .
In terms of health implications, chronically high levels of NAA are associated with Canavan Disease, a genetic disorder characterized by a deficiency of the enzyme aspartoacylase, leading to the accumulation of NAA in the brain and the development of spongy degeneration . On the other hand, decreased concentrations of NAA in the brain have been linked to various neurological disorders, indicating its potential use as a biomarker for brain pathology .
Furthermore, recent research has highlighted the potential of NAA in influencing cellular signaling, particularly in processes such as histone acetylation, and its relevance in diverse tissues beyond the brain, including adipocytes and immune cells. Notably, in cancer cells, an upregulation of NAA synthesis and a downregulation of its degradation have been observed, suggesting a potential signaling role of intact NAA in disease
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