| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Levamlodipine Besylate is a calcium channel blocker primarily used to treat hypertension (high blood pressure). It functions by relaxing blood vessel walls and increasing blood flow, which in turn lowers blood pressure. As the besylate salt of levamlodipine, it is more soluble and better absorbed than the maleate form .
The chemical name for Levamlodipine Besylate is (+)-(S)-3-(ethyl(phenyl)methyl)-5-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate benzenesulfonate (2:1) salt, with a CAS number of 150566-71-5. It is the active (S)-enantiomer of amlodipine, which means it is the form that provides the therapeutic effect, as opposed to the (R)-enantiomer which is inactive .
Pharmacokinetically, Levamlodipine Besylate has a Tmax of 6-12 hours and a bioavailability of 64-90%. It is not significantly affected by food and is highly protein-bound (93%) in plasma, primarily to human serum albumin. Metabolism is mainly through CYP3A4, and approximately 60% of the drug is eliminated in the urine, with about 10% being the unchanged drug .
In clinical trials, Levamlodipine Besylate has been shown to be effective in treating hypertension. It was found to be bioequivalent to amlodipine when given at a 5mg dose compared to amlodipine's 10mg dose. The drug is generally well-tolerated, with side effects being similar to other dihydropyridine calcium channel blockers and may include peripheral edema, dizziness, and headache
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