| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Perindopril Erbumine is an active pharmaceutical ingredient, which is a salt of perindopril and erbumine. It is an angiotensin-converting enzyme (ACE) inhibitor used primarily for the treatment of hypertension and heart failure . The drug acts by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure and afterload on the heart .
Perindopril Erbumine is chemically described as (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt . It is a white crystalline powder with a molecular weight of 441.61 g/mol and a CAS number of 107133-36-8 .
The drug is typically administered orally in tablet form and is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver to its active form, perindoprilat, which has a longer duration of action than the parent drug . Perindopril Erbumine is usually well-tolerated, but side effects can include dizziness, hypotension, cough, and in rare cases, angioedema .
Perindopril Erbumine is contraindicated in patients with hypersensitivity to ACE inhibitors, pregnant women, and those with a history of angioedema related to previous ACE inhibitor treatment . It should be used with caution in patients with renal impairment or a history of liver disease . The medication is also available under various brand names and is prescribed in different strengths, typically starting at a low dose and titrated based on the patient's response and tolerance .
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