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Sodium selenite (Na2SeO3) is an inorganic form of the essential trace element selenium, which is important for high-quality nutrition. It plays a critical role in various physiological processes, including thyroid hormone metabolism, DNA synthesis, and protection against oxidative damage and infection. Here are some key points about sodium selenite and its significance in nutrition:
Antioxidant Properties: Selenium is a component of selenoproteins, such as glutathione peroxidases and thioredoxin reductases, which help protect cells from oxidative damage by neutralizing free radicals .
Immune Function: Selenium contributes to the proper functioning of the immune system. It may enhance immune responses and help to maintain a balanced immune profile .
Thyroid Health: Selenium is crucial for thyroid hormone synthesis and metabolism. It is involved in the conversion of the prohormone T4 to the active T3, and it protects the thyroid gland from oxidative damage .
Cancer Prevention: Some epidemiological studies suggest an inverse association between selenium status and the risk of certain types of cancer. However, clinical trials have had mixed results, and more research is needed to determine the effectiveness of selenium supplementation for cancer prevention .
Cardiovascular Health: While selenium may support heart health by reducing inflammation and preventing lipid oxidation, clinical trials have not conclusively shown that selenium supplementation reduces the risk of cardiovascular disease .
Cognitive Health: Observational studies have associated higher selenium intake with better cognitive function in older adults. However, clinical trials have not definitively shown that selenium supplementation improves cognitive function or prevents cognitive decline .