| Customization: | Available |
|---|---|
| Antibacterial Type: | Chemical Antibacterial, Natural Antibacterial |
| Applied animal classification: | Aquatic Animals, Livestock, Poultry |
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Specifications:
| ANALYSIS ITEM | SPECIFICATION | RESULT |
| Appearance | white powder | Conforms |
| Loss on drying | 10% Max | 5.4% |
| Arsenic Salt | 2ppm Max | Conforms |
| Heavy Metals | 20ppm Max | Conforms |
| Assay | 99.0% | 99.5% |
Trimethoprim is a diaminopyrimidine antimicrobial agent widely used in veterinary medicine due to its effectiveness against a range of Gram-positive and Gram-negative bacteria. Here are some key effects and uses of trimethoprim in animals:
Mechanism of Action: Trimethoprim acts as a competitive inhibitor of the enzyme dihydrofolate reductase, which is crucial for bacterial DNA synthesis. It inhibits this enzyme at much lower concentrations compared to mammalian enzymes, allowing for selective toxicity against bacteria while minimizing effects on animal cells.
Common Uses: Trimethoprim is often used in combination with sulfonamides (like sulfadiazine) to enhance its antibacterial efficacy. This combination is administered orally or via injection to various animals, including cattle, pigs, poultry, and fish, to treat infections such as respiratory and urinary tract infections.
Dosage and Administration: The typical dosage for trimethoprim in combination with sulfonamides is 5 mg/kg of trimethoprim and 25 mg/kg of sulfonamide. Treatments are usually repeated for up to 5 days.
Toxicity and Side Effects: While trimethoprim is generally well tolerated, prolonged use or high doses can lead to adverse effects such as bone marrow suppression, which may result in anemia and other blood disorders. Mild gastrointestinal disturbances can also occur. In some studies, no adverse effects were observed even at doses up to ten times the recommended amount
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