| Customization: | Available |
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| CAS No.: | 4618-18-2 |
| Formula: | C12h22o11 |
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Lactulose is a synthetic disaccharide that plays a significant role in veterinary medicine, particularly for the following functions and benefits in animals:
Laxative Effect: Lactulose acts as an osmotic laxative, helping to treat constipation by retaining water in the colon, softening stools, and stimulating bowel movements.
Ammonia Reduction: It is used to manage hepatic encephalopathy, a neurological condition associated with liver disease, by reducing blood ammonia levels. Lactulose converts ammonia (NH3) to ammonium (NH4+), which is less readily absorbed, thus lowering systemic ammonia levels.
Protection of Intestinal Barrier: Studies suggest that lactulose, when combined with probiotics like Bacillus coagulans, can protect against intestinal morphological damage, barrier dysfunction, and apoptosis in weaned piglets challenged with lipopolysaccharide (LPS), indicating its beneficial effects on performance and resilience to acute immune stress.
Promotion of Beneficial Gut Flora: Lactulose, being a prebiotic, promotes the growth of beneficial bacteria in the gut that preferentially metabolize it and produce short-chain fatty acids, which can further help in acidifying the gut content and support overall gut health.
Modulation of Faecal Microbiota: Lactulose has been shown to induce a reversible reduction and qualitative modulation of faecal microbiota diversity in healthy dogs, affecting both alpha and beta diversity metrics and implicating specific taxa in this change.
Management of Chronic Constipation: Lactulose is used as a third-line agent for chronic constipation once lifestyle modifications and increasing fiber intake have failed, due to its significant reduction of intestinal transit time.
Anti-cancer Potential: Recent studies have looked at lactulose for developing novel anticancer therapeutic agents due to its ability to bind to galectins, a carbohydrate-binding protein that plays a role in tumor progression
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