| Customization: | Available |
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| CAS No.: | 34540-22-2 |
| Formula: | N/a |
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Madecassoside is a significant bioactive saponin compound extracted from the herb Centella asiatica, also known as "Indian pennywort". It has been traditionally used for its wide range of therapeutic effects, including skin conditions, neurological actions, and vascular diseases . Madecassoside has been the subject of scientific research due to its potential in treating various disorders, and it is one of the main constituents responsible for the biological effects of Centella asiatica extracts .
Madecassoside has demonstrated wound healing properties, promoting re-epithelialization and improving healing patterns in burned skin on mice . It also has the ability to protect against lipid peroxidation and stimulate collagen synthesis and expression, which makes it beneficial in skin health and repair . Furthermore, it has shown neuroprotective effects, memory-enhancing capabilities, and antidepressant and anxiolytic properties .
In terms of pharmacokinetics, madecassoside has been studied in comparison with asiaticoside, another major compound in Centella asiatica. Studies have shown variations in the bioavailability and metabolism of these compounds when administered separately or as part of a standardized extract .
The compound has also demonstrated anti-inflammatory and antioxidant properties, which are beneficial in treating acute and chronic diseases. Madecassoside has been found to protect against oxidative stress and UVB radiation, inhibit melanin synthesis, and reduce the transfer of melanosomes in a co-culture system of keratinocytes and melanocytes .
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